New Approaches

There has been so much hopeful news recently about new approaches in treating pulmonary hypertension and in some cases reversing the lung damage caused by this disease, we thought it was time to dedicate a page to the "good news".   Yes, there finally is some good news.

What you will find here is news we have collected in the PHC newsroom that we think deserves special attention.    There seems to be a lot going on in this field right now and we want to celebrate it.  One day pulmonary hypertension may be one of those diseases with a cure.   One day. 

We hope you will come here often to see what's new and what may be possible.  With so many approaches to the disease, things are looking up.

In The News

• May 8, 2012
• Erectile Dysfunction Drug May Benefit Cardiac Function in Young Patients with Heart Defects
• May 5, 2012
• Actelion Gets 'Best Case' Results From Trial of PAH Drug
• May 5, 2012
• Serum osteoprotegerin (OPG) is increased and predicts survival in idiopathic pulmonary arterial hypertension.
• May 4, 2012
• Press Releases VentriPoint Launches Clinical Trial in Pulmonary Arterial Hypertension (PAH) With Top Pulmonary Hypertension Centres in the United States and Canada
• April 30, 2012
• Actelion's macitentan meets primary endpoint in pivotal Phase III SERAPHIN outcome study in patients with PAH
• April 26, 2012
• PET imaging can quantify increased cellular metabolism in pulmonary arterial hypertension
• April 18, 2012
• Stanford scientists show lab-made heart cells ideal for disease research, drug testing
• April 13, 2012
• Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH.
• April 11, 2012
• New Data on GeNO LLC Nitric Oxide Delivery System to be Presented at ISHLT Conference Next Week
• April 6, 2012
• Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.
• March 31, 2012
• Puerarin, an isoflavone purified from a Chinese medicine herb, promotes apoptosis..
• March 31, 2012
• Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans.
• March 24, 2012
• New Approach Improves MR Detection of Pulmonary Embolism
• March 22, 2012
• FDA Clears Expanded Compatibility for INOMAX® Drug-Delivery Systems Read more here: http://www.bradenton.com/2012/03/21/3952912/fda-clears-expanded-compatibility.html#storylink=cpyThe INOMAX DS and INOMAX DSIR are proprietary drug-delivery systems that d
• March 19, 2012
• Novartis launches Arcapta(TM) Neohaler(TM), a novel once-daily bronchodilator for chronic obstructive pulmonary disease
• March 15, 2012
• UF researchers target 'traitor proteins'
• March 10, 2012
• Initial Experience With Tadalafil in Pediatric Pulmonary Arterial Hypertension.
• March 3, 2012
• Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats
• February 27, 2012
• VentriPoint Completes Validation Study for Pulmonary Arterial Hypertension Application
• February 14, 2012
• Doctors find link between migraines, heart condition
• February 5, 2012
• Treating Pulmonary Arterial Hypertension: Current Treatments and Future Prospects
• January 20, 2012
• Studies shed new light on how nitric oxide is produced
• January 17, 2012
•  Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension.
• January 6, 2012
• Heart Attack Hospital Re-Admission Rates Higher In The USA Than Abroad
• December 9, 2011
• Systemic Oxidative Stress and Endothelial Dysfunction is Associated With an Attenuated Acute Vascular Response to Inhaled Prostanoid in Pulmonary Artery Hypertension Patients.
• December 8, 2011
• Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction
• December 7, 2011
• Epigenetic mechanisms of pulmonary hypertension.
• November 22, 2011
•  Breakthrough In Stem Cell Treatments For Heart Patients Says Cedars Sinai Hospital
• November 16, 2011
• CHEST: Oral Prostanoid Shows Promise in PAH
• November 5, 2011
• New and Emerging Anticoagulant Therapy for Atrial Fibrillation and Acute Coronary Syndrome
• November 5, 2011
• New Drug Found Effective in Phase 3 COPD Trials
• October 29, 2011
• Recent Advances in Optical Coherence Tomography for the Diagnoses of Lung Disorders
• October 29, 2011
• European Nod for HG Nerve Stimulation in Sleep Apnea
• October 29, 2011
• Treating Obstructive Sleep Apnea With Hypoglossal Nerve Stimulation
• October 26, 2011
• VIP and endothelin receptor antagonist: An effective combination against experimental PAH
• October 23, 2011
• B-type Natriuretic Peptide or Amino-terminal Pro-B-type Natriuretic Peptide-guided Treatment of Heart Failure
• October 22, 2011
• Resolving Pulmonary Embolism With Ultrasound
• October 18, 2011
• Protein could treat adult pulmonary hypertension
• October 12, 2011
• New Transplant Method May Eliminate Need for Lifelong Medication
• October 6, 2011
• Tyrosine kinase inhibitors are potent acute pulmonary vasodilators in rats.
• October 5, 2011
• Sildenafil improves the beneficial hemodynamic effects exerted by atorvastatin during acute pulmonary thromboembolism.
• October 4, 2011
• How sniffing salt could LOWER blood pressure
• September 27, 2011
• Norvartis' GTI571 (Glivec) - phase III trial IMPRES reached it's primary endpoint
• September 27, 2011
• TXA127 granted orphan drug status for PAH
• September 24, 2011
• Supercomputer Helps Predict Heart-Failure Events
• September 15, 2011
• Stem Cell Company links up with UT, makers of Remodulin
• September 13, 2011
• Novel phosphodiesterase type 5 modulators: a patent survey (2008 - 2010).
• September 11, 2011
• EU Clears Stem Cell Trial for Broken Hearts
• September 11, 2011
• DHEA inhibits the SrC/STAT3 constitutive activation in PAH
• August 31, 2011
•  Intensive Immunosuppresive Therapy Improves Long-Term-Prognosis in PAH due to Connective Tissue Disease
• August 7, 2011
• Neutrophil Elastase Regulator Needed in Systemic Sclerosis
• August 4, 2011
•  Effects of Everolimus in Combination with Sildenafil in Monocrotaline-induced Pulmonary Hypertension in Rats.
• August 1, 2011
• Transgenic expression of human matrix metalloproteinase-1 attenuated pulmonary arterial hypertension in mice
• July 27, 2011
• Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease
• July 26, 2011
•  Pluristem to build new Israeli stem cells facility
• July 22, 2011
• Analysis of endothelin-1 and endothelin-1 receptor A gene polymorphisms in patients with pulmonary arterial hypertension.
• July 22, 2011
• New test to identifiy no-responders in pulmonary arterial hypertension patients
• July 19, 2011
• Richard Feldman: Don't neglect the D factor
• July 15, 2011
• An endothelial progenitor cell capture chip could serve as a rapid bedside test for PAH
• July 13, 2011
• Intralipid Prevents and Rescues Fatal Pulmonary Arterial Hypertension and Right Ventricular Failure in Rats
• July 11, 2011
• Targeted gene delivery of BMPR-2 attenuates pulmonary hypertension
• July 10, 2011
• Dr. Robyn J. Barst to Lead Pulmonary Hypertension Clinical Development Program for Validation of the Ventripoint VMS(TM) Heart Analysis System
• June 20, 2011
• United Therapeutics to developnew treatment based on cells of a placenta
• June 17, 2011
• Comparison of different anticoagulants in pulmonary arterial hypertensive rats
• June 1, 2011
• Levosimendan attenuates pulmonary vascular remodeling - in animal trial
• May 30, 2011
•  Australia: Enrollment of a new trial on the effects of exercise training in PAH patients
• May 30, 2011
• NicOx presents first preclinical data in Pulmonary Arterial Hypertension research program
• May 26, 2011
•  Off topic, but quiet interesting: Sildenafil could reduce multiple sclerosis symptoms
• May 24, 2011
• Value of Impedance Cardiography in Patients Studied for Pulmonary Hypertension.
• May 10, 2011
• The Children's Hospital of Philadelphia Partners with Vascular Magnetics, Inc. to Pursue Commercial Potential of Blood Vessel Research
• April 27, 2011
• Stem Cell Transplant – Enhanced Cord Blood Stem Cell Transplants Found Safe
• April 24, 2011
• Cell Repair Therapy Improves Function in Severe Heart Failure
• April 9, 2011
• At-Home Wireless Pulmonary Artery Pressure Monitor Helps in Heart Failure
• April 4, 2011
•  Live human heart grown in lab using stem cells in potential transplant breakthrough
• April 4, 2011
• Michigan develops its first disease specific embryonic stemcell lines
• April 2, 2011
• Lung Ultrasound: A New Tool for the Cardiologist
• April 2, 2011
• Atrial Septostomy Helpful in Pulmonary Artery Hypertension
• March 21, 2011
• Stem Cell Therapy Shrinks Enlarged Hearts
• March 9, 2011
• Accord Biomaterials receives $1.3M NIH SBIR grant to develop pulmonary hypertension diagnotics
• March 9, 2011
• Combined inhibition of PDE3 and 4 regresses development of pulmonary hypertension
• March 8, 2011
• Research - Protective effects of hydrogen-rich saline
• March 1, 2011
• Study Finds Relationship Between PAH and Blood Cell Abnormalities
• February 24, 2011
• Public Health Care for All
• February 18, 2011
•  Aspirin Attenuates Pulmonary Arterial Hypertension in Rats by Reducing Plasma 5-Hydroxytryptamine Levels.
• February 16, 2011
• Role for miR-204 in human pulmonary arterial hypertension.
• February 14, 2011
• New Approach: Collagen-IV Contributes to Nitric Oxide-induced Angiogenesis of Lung Endothelial Cells
• February 12, 2011
• Researchers Recreate Cardiac Defect in a Lab Dish
• January 29, 2011
• The Role of Asymmetric Dimethylarginine and Arginine in the Failing Heart and its Vasculature
• January 22, 2011
• Scientists Find Inflammation Immune Cell Switch
• January 19, 2011
• EKOS Corporation Receives CE Mark To Treat Massive And Sub-Massive Pulmonary Embolism
• December 27, 2010
• Time-resolved magnetic resonance angiography: Evaluation of intrapulmonary circulation parameters in PAH.
• December 24, 2010
• Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats
• December 10, 2010
• Arena Pharmaceuticals Initiates Phase 1 Clinical Trial of APD811 for Pulmonary Arterial Hypertension
• December 8, 2010
• GeNO Gas Cylinder NITROSYL™ System Testing in PAH
• December 3, 2010
• FDA Clears GeNO LLC's Investigational New Drug
• November 27, 2010
• Phase 2 Trial Finds Therapy Effective for Specific Cystic Fibrosis Mutation
• November 24, 2010
• Transforming growth factor-beta inhibition attenuates pulmonary arterial hypertension in rats.
• November 22, 2010
• Significance of plasma NT-proBNP levels as a biomarker in the assessment of cardiac involvement and PH in patients with sarcoidosis.
• November 11, 2010
• Aires Pharmaceuticals, Inc. Completes $20M
• November 9, 2010
• Stem cell treatment for heart disease coming soon
• November 7, 2010
• Dabigatran Q&A: The Who, When, and How for Switching, Starting, and Stopping the New Oral Anticoagulant
• October 30, 2010
• Protein Shows Promise as a Therapeutic Target in Pulmonary Arterial Hypertension
• October 29, 2010
• Interleukin-6 as a potential therapeutic target for pulmonary arterial hypertension.
• October 25, 2010
• Blood Protein Warns of Pulmonary Hypertension
• October 25, 2010
• Gene Therapy Reverses Pulmonary Hypertension
• October 23, 2010
• Treatment of pediatric pulmonary hypertension with simvastatin: An observational study.
• October 20, 2010
• Stem cell research: a new age dawns in healthcare
• October 15, 2010
• NovaDel Pharma Inc. Announces Positive Data from Pilot Pharmacokinetic Study
• October 6, 2010
• Minimally-Invasive Treatment of Atrial Septal Defect
• October 4, 2010
• YM BioSciences licensee Pulmokine awarded NIH funding for PH
• October 1, 2010
• Harvard researchers creates stem cells from skin
• September 29, 2010
• BGS Global Hospitals Performs Heart Surgeries without Cutting Chest Bone
• September 27, 2010
• Growing replacement lungs may help those in need of a lung transplant to breathe easy
• September 14, 2010
• Gene Therapy Proves Effective in Treating Severe Heart Failure
• September 5, 2010
• Realities and Expectations of Pharmacogenomics and Personalized Medicine: Impact of Translating Genetic Knowledge into Clinical Practice